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Standard Dose Range 150–300 mcg SC 200–400 mcg SC 250–500 mcg SC Higher doses for circadian work due to extended phase-shift windows Injection Timing 60 min pre-sleep 30 min pre-stressor exposure 90 min before target sleep phase …
Typical Dose Range 25–50 mcg IV 60–100 mcg subcutaneous IV requires lower dose due to 100% bioavailability; subcutaneous ~60–70% bioavailability Contemporary protocols favor subcutaneous for multi-day studies due to ease of admin…
1–2 mg 3×/week Mild inflammatory pain 20–30% vs baseline Minimal 2–4 weeks Subtherapeutic for moderate-to-severe pain. Reserve for low-intensity models or combination protocols with NSAIDs 5 mg 3×/week Moderate inflammatory, neur…
0.25mg subcutaneous Subcutaneous 90 minutes Minimal effect in Western replication studies; early Soviet trials reported benefit but peptide purity questioned Insufficient dose for most subjects. Trial only if extreme peptide sens…
Baseline Anxiety Modulation 100–150mcg daily 30–60 min before waking OR bedtime 14–18% reduction in CAR; 12% reduction in PSS-10 scores Minimal. Occasional mild drowsiness in 8% of subjects Best for chronic low-grade stress; cons…
Stress recovery / cortisol regulation 100–200 mcg Subcutaneous 30–60 min before sleep or immediately post-stress 25–35% faster cortisol normalization; reduced stress-induced sleep latency Most cost-effective protocol. Low dose, c…
0.5–1mg CT12 (dark phase onset) Minimal phase shift; increased delta-wave activity in first sleep cycle but no lasting rhythm adjustment Acute sleep architecture studies unrelated to circadian function Pharmacol Biochem Behav (19…
DSIP Modulates hypothalamic sleep-wake switch; reduces evening cortisol 2–2.5 mg SubQ, 3x weekly Increases delta wave density by 25–34%; minimal effect on REM Low. Occasional morning grogginess at >4 mg Best for stress-induced in…
DSIP Delta-opioid receptor modulation + GABAergic potentiation 1–5 ng/kg body weight 60–90 minutes Slow-wave sleep (Stage 3 NREM) Best for deep sleep enhancement without REM suppression. Requires nanogram-level precision Epithalo…
Different DSIP protocols emphasize either frequency or total dose depending on the stress pattern being addressed. The table below compares three evidence-based approaches. | Protocol Type | Dose Per Injection | Frequency | Total…
DSIP 150–500mcg SC/IV Opioid receptor sensitisation, substance P inhibition 30–90 min (SC), 10–20 min (IV) 4–8 hours acute; cumulative over weeks High. Widely synthesised Best for chronic pain potentiation; requires consistent do…
Conservative Initiation 50–100mcg 7–14 nights Subcutaneous, 30–60 min pre-sleep Baseline SWS assessment; minimal next-day sedation Standard Maintenance 100–200mcg 14–28 nights 18–26% increase in delta-wave density; measurable cor…
Jet Lag Recovery 0.25 mg 0.5–1 mg Increase 0.1 mg every 5 days DLMO advancement, CAR normalization Effective for 3+ time zone shifts; less useful for 1–2 zones where light therapy alone suffices Shift Work Adaptation 0.1 mg 0.5–1…
Fixed Mass Dose Convert target mcg to mg, divide by concentration (mg/mL) to get volume Protocols where all subjects receive identical absolute dose regardless of body weight ±0.01mL with insulin syringe (±2.5mcg at 2.5mg/mL) Sim…
1mg SC 30–60 min pre-sleep Mild delta wave improvement (10–15% vs baseline) in controlled trials Minimal. Sustainable long-term Ideal starting dose for titration; establishes baseline response without tolerance risk 1.5–2mg SC Mo…
2mg 1mL 2.0 2000 0.125mL 0.25mL 0.01mL graduations 2mL 1.0 1000 0.50mL 5mg 2.5 2500 0.10mL 0.20mL 5mL 10mg 5.0 5000 0.05mL Higher concentrations require smaller injection volumes, increasing measurement precision demands. The 10m…