Understand the source comparison
DSIP Dosage Protocol: Research Applications Comparison
Standard Dose Range 150–300 mcg SC 200–400 mcg SC 250–500 mcg SC Higher doses for circadian work due to extended phase-shift windows Injection Timing 60 min pre-sleep 30 min pre-stressor exposure 90 min before target sleep phase Timing precision matters more t
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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Standard Dose Range
- 150–300 mcg SC
- 200–400 mcg SC
- 250–500 mcg SC
- Higher doses for circadian work due to extended phase-shift windows
- Injection Timing
- 60 min pre-sleep
- 30 min pre-stressor exposure
- 90 min before target sleep phase
- Timing precision matters more than dose magnitude
- Cycle Duration
- 5 days on / 2 days off
- Single administration per protocol
- 3–5 day intensive phase
- Stability ceiling dictates max cycle length
- Reconstitution Volume
- 1mg/1mL standard
- 2mg/2mL for multi-dose
- Higher concentrations don't extend stability
- Storage Requirements
- 2–4°C, <96 hours
- 2–4°C, single-use vial
- 2–4°C, <72 hours preferred
- Temperature excursions are unrecoverable failures
- Expected Outcome Measure
- Delta power density +15–25%
- Cortisol AUC reduction 10–18%
- Phase shift 45–90 minutes
- Effect sizes modest—requires objective measurement