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Best DSIP Dosage for Stress Reduction: Protocol Comparison
Baseline Anxiety Modulation 100–150mcg daily 30–60 min before waking OR bedtime 14–18% reduction in CAR; 12% reduction in PSS-10 scores Minimal. Occasional mild drowsiness in 8% of subjects Best for chronic low-grade stress; consistent but modest effect Modera
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- Baseline Anxiety Modulation
- 100–150mcg daily
- 30–60 min before waking OR bedtime
- 14–18% reduction in CAR; 12% reduction in PSS-10 scores
- Minimal. Occasional mild drowsiness in 8% of subjects
- Best for chronic low-grade stress; consistent but modest effect
- Moderate Perceived Stress
- 200–300mcg daily
- 45–60 min before anticipated stressor OR bedtime
- 19–23% reduction in salivary cortisol at 2-hour mark
- Daytime drowsiness in 15%; transient headache in 6%
- Effective for work-related or situational stress; timing-dependent
- Acute Stress Intervention
- 400–500mcg as-needed
- 30 min before acute stressor (not daily)
- 28–32% reduction in peak cortisol; 40% faster symptom resolution
- Rebound anxiety in 15%; sedation in 22%
- Highest immediate effect but not sustainable long-term
- Circadian Cortisol Reset
- 200mcg nightly × 14 days
- 30 min before bed
- 21% reduction in next-morning CAR after 2 weeks
- Sleep architecture disruption in 11% (increased N2, reduced REM)
- Useful for shift workers or jet lag recovery; limited to short cycles