Understand the source comparison
DSIP Dosage Circadian Rhythm 2026: Protocol Comparison
Jet Lag Recovery 0.25 mg 0.5–1 mg Increase 0.1 mg every 5 days DLMO advancement, CAR normalization Effective for 3+ time zone shifts; less useful for 1–2 zones where light therapy alone suffices Shift Work Adaptation 0.1 mg 0.5–1.5 mg Increase 0.1 mg every 7 d
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Jet Lag Recovery
- 0.25 mg
- 0.5–1 mg
- Increase 0.1 mg every 5 days
- DLMO advancement, CAR normalization
- Effective for 3+ time zone shifts; less useful for 1–2 zones where light therapy alone suffices
- Shift Work Adaptation
- 0.1 mg
- 0.5–1.5 mg
- Increase 0.1 mg every 7 days
- Sleep latency reduction, total sleep time increase
- Requires consistent dosing at new schedule time; ineffective if shift rotates weekly
- Delayed Sleep Phase Disorder
- 0.2 mg
- 1–2 mg
- Increase 0.15 mg every 10 days
- Phase advancement measured via actigraphy, morning cortisol timing
- Most robust evidence base; works best combined with morning bright light exposure
- Chronic Stress-Induced Insomnia
- 0.15 mg
- Increase 0.1 mg every 7–10 days
- Cortisol awakening response flattening, subjective sleep quality
- Addresses root HPA dysregulation; ineffective if stressor remains unmanaged
- General Circadian Optimization
- 0.25–0.5 mg
- Hold at starting dose 4 weeks before increasing
- Sleep onset consistency, waking time variability reduction
- Preventive use in healthy individuals—evidence limited but mechanistically sound