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Just as you could not stand tall or move without your bony frame, each neuron has its own skeletal scaffold of interconnected tubes of protein that gives it shape, traffics cargo, and allows it to move. The SP…
Read guide →Cartilage neither heals nor regenerates after damage, so artificial cartilage could help many people with joints damaged by wear, injury or disease. Lab-grown cartilage grown with tension (top) shows similar m…
Read guide →Investigators at the University of North Carolina at Chapel Hill Structural Genomics Consortium (SGC-UNC)—in partnership with the DiscoverX Corporation—have reached the halfway point in their development of a …
Read guide →Making medicines is a stressful business, literally. Bioprocessing technologies, cleaning agents, and even packaging can create stresses that impact drug quality. Understanding these stresses is the first step…
Read guide →Ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO), the world’s most abundant protein, adopts multiple assemblies, although the origins and distribution of its different oligomeric states remain cryptic…
Read guide →Continuous manufacturing processes are helping drug firms intensify output. But the large volumes of waste media they generate are a concern from a sustainability perspective, according to Merck & Co. engineer…
Read guide →Researchers at Harvard say they have converted skin cells from patients with early-onset Alzheimer’s into the types of neurons that are affected by the disease. They note that this makes it possible for the fi…
Read guide →Zydus Cadila and therapeutic protein R&D firm Pieris have forged an alliance to develop and commercialize multiple novel Anticalin®-based protein therapeutics. Per the agreement, Zydus will advance Anticalin d…
Read guide →When attempting to master a new subject, it is usually advisable to seize its trunk, and avoid flailing about the branches. With proteins, however, most studies have focused on side chains, not backbones. Alte…
Read guide →Scientists from the Riken Brain Science Institute in Japan report that the lack of autophagy in neurons prevents the secretion of amyloid beta and the formation of amyloid beta plaques in the brain. They belie…
Read guide →A protein involved in bone formation and calcification has provided new insights into the development of smoking-related cardiovascular disease and may represent a new biomarker for assessing the harmful effec…
Read guide →Scientists suggest that a protein known as thioredoxin-interacting protein (TXNIP) could represent a new target for diabetes and potentially other human diseases such as Wolfram syndrome that are associated wi…
Read guide →This illustration shows how an engineered immunomodulatory protein facilitates destruction of latently HIV-infected immune cells. Note that the protein has a yellow CD3-binding end as well as a thick, black HI…
Read guide →Shanghai Fosun Pharmaceutical (Group) will acquire Gland Pharma for up to $1.26 billion, Gland said today. The deal will add the Indian-based maker of generic injectable drugs to the Chinese-based global resea…
Read guide →While biomarkers may be used to diagnose disease, the ups and downs of biological molecules may not depend entirely on whether a particular disease is present. Protein levels in the blood stream, for example, …
Read guide →Scientists from the University of California-Davis have discovered an important difference between mice and humans regarding: how human livers heal. The difference centers on a protein called PPARα, which acti…
Read guide →New research shows proteinaceous foam that forms nests of the túngara frog (Engystomops pustulosus), a native of Trinidad, can encapsulate a variety of hydrophobic and hydrophilic compounds and release them st…
Read guide →Research headed by scientists at the National Institute of Dental and Craniofacial Research (NIDCR) has shown how blocking the function of the blood clotting protein, fibrin, prevents bone loss from periodonta…
Read guide →Researchers have created a map of all 1578 licensed drugs and their mechanisms of action as a means of identifying “uncharted waters” in the search for future treatments. Their analysis of drugs licensed throu…
Read guide →Medicenna BioPharma established a sponsored research agreement with the University of Texas MD Anderson Cancer Center to develop fusion protein therapeutics targeting the interleukin-4 receptor (IL4R). The par…
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