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Kisspeptin-10 operates at the hypothalamic level by binding GPR54 (KISS1R) receptors on GnRH neurons, triggering calcium influx and depolarization that releases endogenous GnRH in physiological pulse patterns. Typically 90-minute…
Kisspeptin-54 GnRH neuron activation Restoring ovulatory cycles in hypothalamic amenorrhea Strong (RCTs published in JCEM) Requires pulsatile administration; no benefit in ovulatory women Proven mechanism in specific diagnostic c…
GnRH Analogs Hypothalamic-pituitary axis ART protocols, ovulation induction models, hypogonadism studies Receptor agonism (short-term stimulation) or desensitization (long-term suppression) Require precise sequencing at positions…
Kisspeptin-10 GPR54 agonist. Triggers GnRH neuron activation 0.3–9.6 nmol/kg IV 28 minutes −20°C lyophilized; 2–8°C reconstituted (use within 7 days) Most precise tool for studying acute GnRH release. Short half-life means tempor…
Growth Hormone Secretagogues (MK 677, CJC-1295/Ipamorelin) Amplify pulsatile GH release → elevate IGF-1 → improve follicle maturation and Leydig cell function Pituitary gland, ovarian granulosa cells, testicular Leydig cells 12.5…
The table below summarizes key peptide candidates, their primary mechanism, typical research dosing ranges, and evidence quality. This comparison is for educational reference. Dosing decisions in human fertility protocols require…