Understand the source comparison
Research Peptides for Fertility: Peptide Integrity and Bioavailability Comparison
Kisspeptin-10 GPR54 agonist. Triggers GnRH neuron activation 0.3–9.6 nmol/kg IV 28 minutes −20°C lyophilized; 2–8°C reconstituted (use within 7 days) Most precise tool for studying acute GnRH release. Short half-life means temporal control GnRH (native) GnRH r
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- Kisspeptin-10
- GPR54 agonist. Triggers GnRH neuron activation
- 0.3–9.6 nmol/kg IV
- 28 minutes
- −20°C lyophilized; 2–8°C reconstituted (use within 7 days)
- Most precise tool for studying acute GnRH release. Short half-life means temporal control
- GnRH (native)
- GnRH receptor agonist. Stimulates LH/FSH release from pituitary
- 25–100 ng/kg pulsatile SC every 90 min
- 2–4 minutes
- −20°C lyophilized; 2–8°C reconstituted
- Requires programmable pump for physiological pulsatility. High technical complexity
- Leuprolide (GnRH agonist)
- GnRH receptor agonist. Initial surge then downregulation
- 1 mg/day SC (depot formulations available)
- 3 hours (immediate-release)
- Room temperature (depot); 2–8°C (solution)
- Useful for pituitary suppression models. Not suitable for acute signaling studies
- Cetrorelix (GnRH antagonist)
- Competitive GnRH receptor antagonist
- 0.25–3 mg/day SC
- 12.5 hours
- 2–8°C
- Immediate suppression without flare. Preferred for controlled FSH-only stimulation
- FSH-beta fragment (33–53)
- FSH receptor partial agonist
- 10–50 mcg/kg IV
- 90 minutes
- −20°C lyophilized; use reconstituted within 48 hours
- Short half-life ideal for acute receptor studies. Avoid for multi-day protocols
- Neurokinin B (NKB)
- NK3 receptor agonist. Stimulates kisspeptin neurons
- 1–10 nmol/kg IV
- 15 minutes
- Critical for studying GnRH pulse frequency. Pairs well with kisspeptin
- hCG (human chorionic gonadotropin)
- LH receptor agonist
- 250–10,000 IU IM or SC
- 24–36 hours
- 2–8°C (liquid); room temp (lyophilized before reconstitution)
- Long half-life problematic for pulsatile studies. Better for sustained LH receptor activation