Understand the source comparison
How to Use Peptides for Fertility: Category vs Mechanism Comparison
Growth Hormone Secretagogues (MK 677, CJC-1295/Ipamorelin) Amplify pulsatile GH release → elevate IGF-1 → improve follicle maturation and Leydig cell function Pituitary gland, ovarian granulosa cells, testicular Leydig cells 12.5–25 mg daily (MK 677) or 200–30
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- Growth Hormone Secretagogues (MK 677, CJC-1295/Ipamorelin)
- Amplify pulsatile GH release → elevate IGF-1 → improve follicle maturation and Leydig cell function
- Pituitary gland, ovarian granulosa cells, testicular Leydig cells
- 12.5–25 mg daily (MK 677) or 200–300 mcg before bed/upon waking (CJC/Ipa)
- 8–12 weeks for IGF-1 elevation; 12–16 weeks for reproductive markers
- Best suited for individuals with suboptimal IGF-1 (<180 ng/mL) and elevated FSH. Not a first-line intervention if baseline GH/IGF-1 is normal
- Thymic Peptides (Thymalin)
- Restore thymic hormone output → modulate T-cell populations → improve endometrial immune tolerance
- Thymus, endometrial tissue, systemic immune regulation
- 5–10 mg daily for 10 days, then 20-day washout, repeat cycle
- 4–6 weeks for T-cell population shift; 8–12 weeks for clinical markers
- Most relevant in recurrent implantation failure or suspected autoimmune activity. Limited value if immune markers are normal
- Mitochondrial Support Peptides
- Enhance mitochondrial biogenesis and reduce oxidative stress in gametes
- Oocytes, sperm cells, mitochondrial DNA repair pathways
- Varies by compound. Typically daily dosing
- 90–120 days (full gametogenesis cycle)
- Longest timeline to measurable outcome. Requires commitment to full reproductive cycle before evaluation