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Before selecting a peptide, understand which memory pathway is impaired. Cholinergic deficiency presents differently than neurotrophic insufficiency or mitochondrial dysfunction. And the compounds that address each are mechanisti…
Dihexa HGF mimetic; c-Met receptor activation → synaptogenesis 0.1–2 mg/kg (subcutaneous or oral) Oral: 50–60%; Subcutaneous: ~100% 28 days at 2–8°C Highest potency-per-dose; oral administration viable; limited human safety data …
Cerebrolysin BDNF/NGF mimetic. TrkB receptor activation Passive diffusion (400–800 Da peptides) 2.5–5 mL/kg body weight Refrigerate at 2–8°C; 28-day post-reconstitution window Most extensively studied neuropeptide. 200+ trials in…
Cerebrolysin Multi-peptide neurotrophic factor mimetic. Promotes synaptogenesis and reduces excitotoxicity 6 RCTs in vascular dementia (Cochrane 2019). Modest ADAS-cog improvement, high bias risk 10–30mL IV infusion, 5 days/week,…