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Peptides for Memory Loss Prevention — Comparison
Cerebrolysin Multi-peptide neurotrophic factor mimetic. Promotes synaptogenesis and reduces excitotoxicity 6 RCTs in vascular dementia (Cochrane 2019). Modest ADAS-cog improvement, high bias risk 10–30mL IV infusion, 5 days/week, 4 weeks Requires clinical admi
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- Cerebrolysin
- Multi-peptide neurotrophic factor mimetic. Promotes synaptogenesis and reduces excitotoxicity
- 6 RCTs in vascular dementia (Cochrane 2019). Modest ADAS-cog improvement, high bias risk
- 10–30mL IV infusion, 5 days/week, 4 weeks
- Requires clinical administration. Not practical for self-directed prevention protocols
- Strongest human evidence but limited to post-stroke/dementia populations, not prevention
- Dihexa
- HGF receptor agonist. Triggers synaptogenesis at picomolar concentrations
- None. Preclinical rodent models only
- Extrapolated: 1.7–17mg SC, dosing frequency unknown
- No published human pharmacokinetics. Dosing is speculative
- Promising mechanism but entirely untested in humans
- P21
- CNTF-derived BDNF modulator. Enhances memory consolidation and LTP
- None. Rodent spatial memory studies only
- Extrapolated: 17mg SC, 3–5x weekly
- Bioavailability after SC injection unverified in humans
- Mechanistically sound but lacks any human validation
- Thymalin
- Thymic peptide. Reduces neuroinflammation via cytokine modulation
- Observational immune studies. No cognitive-specific RCTs
- 5–10mg SC daily or every other day, 10–20 day cycles
- Indirect cognitive effects through inflammation. Not a direct memory modulator
- Plausible neuroprotective role but no direct memory loss prevention data
- MK 677
- Growth hormone secretagogue. Increases IGF-1 and REM sleep quality
- Phase II trials in elderly (JCEM 1999). IGF-1 increased 72%, no cognitive endpoints measured
- 10–25mg oral daily
- Indirect cognitive benefit through sleep and IGF-1. Not a targeted memory compound
- Improves factors correlated with memory (sleep, GH axis) but not proven to prevent memory loss