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Hexarelin represents the most potent growth hormone-releasing peptide in the GHRP class. Binding affinity studies show it activates GHS-R1a receptors approximately 20% more strongly than ipamorelin or GHRP-2. A 1998 study in the …
Thymosin Alpha-1 Thymic hormone analog. Promotes T-cell maturation and differentiation in thymus Adaptive immunity (T-cell populations) 2–3 times per week subcutaneously 28 days in bacteriostatic water Chronic viral infections, i…
Thymalin Immune modulation. Upregulates CD4+ T-cells, suppresses neuroinflammatory cytokines (TNF-α, IL-6) Indirect. Peripheral immune signals cross BBB; peptide itself does not 5–10 mg SC daily × 10–20 days (human equivalent ~0.…
The table below compares the three most studied anti-inflammatory peptides for gut conditions. Each peptide targets a different mechanism. Selecting the right one requires matching the inflammatory pathway to the peptide's recept…
The best peptides for Alzheimer's prevention work through immune modulation rather than direct amyloid clearance. Thymalin, a thymic peptide, upregulates CD4+ T-cell function and suppresses pro-inflammatory cytokines (TNF-α, IL-6…
Thymalin Thymulin receptor agonist. Restores T-cell differentiation Pre-T cells, CD4+/CD8+ populations 5–10mg subcutaneous every 3–5 days Injection only (oral bioavailability near zero) Most direct immune restoration mechanism. R…
Thymalin Thymic regeneration, T-cell maturation Immune exhaustion, T-cell depletion, thymic atrophy Clinical trials in viral recovery (Russia), observational data 10mg SC daily × 10 days Most direct mechanism for addressing docum…
MK 677 Ghrelin receptor agonist → GH/IGF-1 elevation 12.5–25mg once daily Oral (capsule) or sublingual IGF-1 → PI3K/AKT → hTERT transcription N/A (oral formulation stable at room temp) Epithalon Direct chromatin interaction near …
Thymalin Thymic immune modulation. Restores T-regulatory cell output and reduces IL-6 signalling Immune dysregulation with elevated cytokines or reduced NK cell function 5–10 mg subcutaneous 3× weekly for 4–6 weeks Russian immuno…
To use peptides for longevity effectively, start by identifying which aging pathway you're addressing. Longevity isn't one mechanism. It's a cascade of interconnected processes. Cellular senescence (the accumulation of 'zombie ce…
Semaglutide GLP-1 receptor agonist. Slows gastric emptying, extends satiety signaling 90–120 min post-meal Strong (Phase 3 RCTs, FDA-approved for weight management) 0.25–2.4mg weekly subcutaneous Emotional eating driven by rapid …
Cerebrolysin BDNF/NGF mimetic. Reduces apoptosis, promotes synaptic plasticity Acute (0–14 days) Six RCTs, n=1,773 TBI patients. 23% mortality reduction, improved GOS scores Requires IV administration, expensive, temperature-sens…
MK 677 Ghrelin receptor agonist (GHS) Growth hormone → IGF-1 → lipolysis & protein synthesis 10–25 mg oral, daily Best for sustained metabolic optimization and recovery speed. 24-hour GH elevation without pulsatile crashes Hexare…
Thymalin Thymic epithelial cell restoration, increases naïve T-cell production Corrects the thymic involution that permits EBV reactivation; restores CD4+/CD8+ ratio 10mg SC daily × 10 days, monthly cycles Moderate (Phase II data…
This table compares nootropic peptide categories by primary mechanism, onset timeline, and cognitive domain targeted. Essential context for matching compounds to specific focus deficits. BDNF Modulators (Dihexa, P21) Upregulate b…
MK 677 (Ibutamoren) Ghrelin receptor agonist → GH/IGF-1 elevation +1.1kg lean mass over 2 years (JCEM trial) 25mg daily oral Strongest evidence for lean mass increase; requires resistance training for functional strength gains CJ…
Immune senescence reversal Thymalin Thymic epithelial cell regeneration → increased naïve T-cell output 5–10mg every 10 days for 30–60 days Administer in morning fasted state Most underutilised longevity intervention. Immune agin…
This table compares the three primary peptides used in gut inflammation research protocols, detailing mechanisms, dosing, and clinical application. BPC-157 Upregulates VEGF, promotes angiogenesis, stabilises gastric mucosa 250–50…
Not all peptides marketed for sleep have equivalent evidence. Some target symptom suppression. Others address root mechanisms. This table compares the peptides with documented relevance to shift work sleep disorder. Epithalamin (…
Thymalin Thymic restoration → Treg production → aromatase suppression 5–10 mg reconstituted, 1 mg SC daily × 10 days Subcutaneous injection −20°C before reconstitution; 2–8°C after, use within 28 days Strongest mechanistic ration…