Understand the source comparison
How to Use Peptides for Longevity: Protocol Comparison
Immune senescence reversal Thymalin Thymic epithelial cell regeneration → increased naïve T-cell output 5–10mg every 10 days for 30–60 days Administer in morning fasted state Most underutilised longevity intervention. Immune aging drives systemic inflammation
No winner is assigned.
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- Immune senescence reversal
- Thymalin
- Thymic epithelial cell regeneration → increased naïve T-cell output
- 5–10mg every 10 days for 30–60 days
- Administer in morning fasted state
- Most underutilised longevity intervention. Immune aging drives systemic inflammation that accelerates all other aging pathways
- Telomere maintenance
- Epithalon
- Telomerase activation → TTAGGG repeat extension
- 5–10mg nightly for 10–20 days, cycled every 4–6 months
- Bedtime administration during natural melatonin peak
- Evidence strongest in animal models; human telomerase data limited to small cohorts but mechanistically sound
- Mitochondrial biogenesis
- SLU-PP-332
- ERRα agonist → PGC-1α upregulation and mitochondrial gene transcription
- 1–3mg daily for 8–12 weeks
- Morning administration in fasted state before aerobic activity
- Newer compound with promising Phase 1 safety data; enhances exercise-induced mitochondrial adaptations
- Autophagy enhancement
- Dihexa
- BDNF upregulation → synaptic plasticity and protein clearance
- 1–5mg 3× weekly
- Administer 12–16 hours into fasting window
- Cognitive benefits well-documented; autophagy mechanism indirect but meaningful
- Growth hormone optimisation
- MK-677
- Ghrelin receptor agonist → pulsatile GH release
- 10–25mg nightly
- 30–45 minutes before sleep
- Raises IGF-1 reliably but may suppress autophagy. Avoid stacking with mTOR inhibitors