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Best Peptides for Age Related Muscle Loss: Mechanism Comparison
MK 677 (Ibutamoren) Ghrelin receptor agonist → GH/IGF-1 elevation +1.1kg lean mass over 2 years (JCEM trial) 25mg daily oral Strongest evidence for lean mass increase; requires resistance training for functional strength gains CJC-1295/Ipamorelin Extended-rele
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- MK 677 (Ibutamoren)
- Ghrelin receptor agonist → GH/IGF-1 elevation
- +1.1kg lean mass over 2 years (JCEM trial)
- 25mg daily oral
- Strongest evidence for lean mass increase; requires resistance training for functional strength gains
- CJC-1295/Ipamorelin
- Extended-release GHRH + selective ghrelin mimetic
- Sustained GH elevation without cortisol spike
- 100mcg each, 2–3x weekly subcutaneous
- Preferred for pulsatile GH secretion pattern; minimal side effects
- Hexarelin
- Potent GHRP + direct CD36 receptor activation
- +2.8% lean mass in 16 weeks (frail elderly)
- 2mcg/kg body weight, twice daily
- Most potent secretagogue; potential desensitisation with chronic use
- Collagen Peptides (hydrolysed)
- Fibroblast signaling → endogenous collagen synthesis
- +65% PINP (collagen synthesis marker)
- 15g daily, pre-exercise timing
- Essential for tendon/fascia integrity; synergistic with resistance training
- BPC-157
- VEGF upregulation + TNF-α inhibition
- Accelerated repair in tendon injury models (preclinical)
- 250–500mcg daily subcutaneous (research)
- Strongest evidence for injury recovery; human muscle trials limited
- Thymalin
- T-cell regulation + IL-6 reduction
- −30% circulating IL-6 in elderly (Moscow Institute)
- 10mg intramuscular, 10-day cycles
- Reduces inflammatory muscle catabolism; immune modulation primary target