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All peptides discussed on this page are research compounds supplied for laboratory and scientific investigation under Research Use Only (RUO) conditions. They are not approved medicines, are not intended for h…
Read guide →REVIEW article Front. Aging Neurosci. , 08 March 2021 Sec. Parkinson’s Disease and Aging-related Movement Disorders Volume 13 - 2021 | https://doi.org/10.3389/fnagi.2021.646726 Abstract Parkinson’s disease (PD…
Read guide →Mike KS Chan Michelle BF Wong Wenyi Guo Michael Alexander Yuriy Nalapko Jonathan RT Lakey *Corresponding author: Jonathan R T Lakey, Department of Surgery, University of California Irvine, Irvine, California, …
Read guide →Modifying the activity of the gene that becomes mutated in Parkinson's disease may alter disease progression. Scientists have found specific genetic mutations that appear to have a role in Parkinson’s disease.…
Read guide →Apr 12, 2021 In Parkinson's disease, the death of substantia nigra dopamine-producing neurons unleashes a sequel of progressive motor and non-motor dysfunctions. There is no cure for this neurodegenerative dis…
Read guide →Search for topics, articles, videos, research, etc... Hit enter to search or ESC to close Study Rationale: Excess CDK5 protein kinase activity in the brain caused by the binding of CDK5 with another protein ca…
Read guide →The new peptide shows promise as a drug precursor to treat Parkinson's disease, often known for its distinctive hand tremors. A molecule that shows promise in preventing Parkinson’s disease has been refined by…
Read guide →Introduction Parkinson’s disease is a neurodegenerative condition typically observed in older individuals, characterized by a gradual onset and progressive nature. The initial manifestation often includes trem…
Read guide →BACKGROUND Parkinson’s disease is a disabling and progressive neurological disorder characterized by degeneration of dopamine-producing neurons. Current therapies to replace dopamine are only symptomatic and a…
Read guide →In Alzheimer's, Parkinson's, and type 2 diabetes, harmful protein aggregates and deposits, known as amyloid plaques, develop. There is also much evidence that these three diseases are interconnected and mutual…
Read guide →Scientists from the University of Bath, working together with researchers at the Universities of Oxford and Bristol, have created a molecule that stops a key protein linked to Parkinson’s disease and certain d…
Read guide →Objective/Rationale: Recently we have demonstrated that NF-kB activation is induced in vivo in the SNpc of Parkinson's disease patients and an MPTP-pre-clinical model, and that selective inhibition of NF-kB by…
Read guide →Neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and Amyotrophic Lateral Sclerosis, also known as (ALS), affect millions of people worldwide and significantly imp…
Read guide →Researchers at the University of Bath, in collaboration with the Universities of Oxford and Bristol, have developed a molecule that prevents the clumping and build-up of a protein linked to Parkinson’s disease…
Read guide →Abstract Peptides and their mimetics are increasingly recognised as drug-like molecules, particularly for intracellular protein-protein interactions too large for inhibition by small molecules, and inaccessibl…
Read guide →Introduction Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the selective degeneration of dopaminergic neurons in the substantia nigra and the pathological accumulation o…
Read guide →Objective/Rationale: Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) is currently one of the most potent factors protecting and rescuing neurons in pre-clinical models of Parkinson’s disease. We fou…
Read guide →Researchers at the Federal University of São Paulo (UNIFESP) in Brazil have discovered a new strategy that may protect neurons and other brain cells involved in Parkinson's disease in the future. The results o…
Read guide →Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disease and is typically associated with progressive motor and non-motor dysfunctions. Currently, dopamine replacement therapy is m…
Read guide →Researchers at the University of Bath, in collaboration with the Universities of Oxford and Bristol, have developed a molecule that prevents the clumping and build-up of alpha-synuclein, a protein linked to Pa…
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