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In vitro anti-inflammatory activity Confirmed. NF-κB inhibition demonstrated in multiple cell lines (UCLA 2019, Monash 2020) Hypothesized. Same pathways elevated in Hashimoto's but not directly tested Mechanism plausibility is hi…
Primary Action Upregulates endogenous melatonin synthesis via mitochondrial stabilization in pineal neurons Exogenous receptor agonism. Binds MT1/MT2 receptors to signal sleep onset GABA-A receptor modulation. Enhances inhibitory…
LL-37 Membrane disruption + cytokine regulation 54–68% biofilm reduction at 4 μg/mL (P. aeruginosa, S. aureus) Balanced IL-8/IL-10, reduced IL-17A, EGFR activation Phase II (topical irrigation) Most studied cathelicidin for CRS. …