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B.V. Zlokovic et al. Blood-brain barrier permeability to leucine-enkephalin, d -alanine 2 - d -leucine 5 -enkephalin and their N-terminal amino acid (tyrosine) Brain Res. (1985) K.R. Duffy et al. Blood-brain b…
Read guide →Designed for biological research and industrial applications, not intended for individual clinical or medical purposes. Targeting peptides provide a non-invasive and receptor-mediated strategy to shuttle thera…
Read guide →Introduction Central nervous system (CNS) targeted therapeutic research is mostly directed towards identification of optimized drugs and formulations demonstrating properties for CNS exposure whilst less effor…
Read guide →Summary: Researchers have developed a cyclic peptide that can enhance blood-brain barrier penetration. Source: Kumamoto University A Japanese research team has developed a cyclic peptide (a chain of amino acid…
Read guide →. Author manuscript; available in PMC: 2018 Aug 12. Abstract Peptides and proteins have potent effects on the brain after their peripheral administration, suggesting that they may be good substrates for the de…
Read guide →Abstract The intranasal route has emerged as a promising strategy that can direct delivery of drugs into the systemic circulation because the high-vascularized nasal cavity, among other advantages, avoids the …
Read guide →Penn Engineers have modified lipid nanoparticles (LNPs) — the revolutionary technology behind the COVID-19 mRNA vaccines — to not only cross the blood-brain barrier (BBB) but also to target specific types of c…
Read guide →Introduction The development of non-invasive therapeutics that can be administered intravenously remains a challenge for the treatment of neurological disorders, including glioma, Alzheimer’s disease (AD), and…
Read guide →Designed for biological research and industrial applications, not intended for individual clinical or medical purposes. Creative Peptides provides peptide modification services to enhance brain-specific drug d…
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Read guide →Introduction To successfully deliver its cargo to a target tissue, a nanocarrier must navigate through the body while eliciting minimal immunogenic response and avoiding off-target delivery of cytotoxic compou…
Read guide →Abstract The brain is a complex, regulated organ with a highly controlled access mechanism: The Blood-Brain Barrier (BBB). The selectivity of this barrier is a double-edged sword, being both its greatest stren…
Read guide →Summary The blood–brain barrier (BBB) is a selectively permeable interface formed by specialised endothelial cells, tight junctions and supporting pericytes and astrocytic endfeet. Its principal role is to mai…
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