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Peptide-based brain distribution improvement strategies for ...
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Show {{imgMenuList.length - 9}} more figures Hide {{imgMenuList.length - 9}} figures Show {{tableMenuList.length - 5}} more tables Hide {{tableMenuList.length - 5}} tablesReview Article | Open Access
Xiaoxi Chang1, Chenyan Lv1, Jiachen Zang1, Guanghua Zhao1, Tuo Zhang1,2 ( )
1College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
2Center of Food Colloids and Delivery for Functionality, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
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Abstract
Central nervous system disorders constitute a major global public health burden, contributing substantially to morbidity and mortality. Advances in elucidating their underlying pathogenesis have facilitated the approval of an increasing number of proprietary drugs for clinical management of neurological conditions. A critical challenge in drug delivery lies in achieving appropriate tissue distribution, particularly within the brain, where effective therapeutic intervention requires traversing the blood-brain barrier and precisely targeting localized regions. Nanodelivery systems have emerged as a promising approach in biomedicine to address these challenges. Among these, peptides—characterized by their high specificity and relatively small size—are extensively employed to functionalize nanocarriers, thereby enhancing targeted tissue distribution. The conjugation of diverse functional peptides onto heterogeneous nanoscale carriers enables precise, efficient, and multidimensional targeting. This review highlights several representative neurological diseases and systematically discusses strategies for peptide-based functionalization of nanocarriers tailored to these pathological contexts.
Graphical Abstract
This review summarized surface modification with blood-brain barrier (BBB)-shuttling peptides, targeted transport across the blood-brain barrier and site-specific drug release in pathological brain regions.
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Article number: 94907916
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Review Status: {{reviewData.commendedNum}} Commended , {{reviewData.revisionRequiredNum}} Revision Required , {{reviewData.notCommendedNum}} Not Commended Under Peer Review
Cite this article:
Qian Y, Chang X, Lv C, et al. Peptide-based brain distribution improvement strategies for nano delivery systems in CNS diseases treatment. Nano Research, 2025, 18(11): 94907916. https://doi.org/10.26599/NR.2025.94907916
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Received: 25 June 2025
Revised: 07 August 2025
Accepted: 12 August 2025
Published: 10 September 2025
© The Author(s) 2025. Published by Tsinghua University Press.
This is an open access article under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0, https://creativecommons.org/licenses/by/4.0/).