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Abstract Breast Cancer (BC) is the most common cancer worldwide and, despite the advancements made toward early diagnosis and novel treatments, there is an urgent need to reduce its mortality. The Gastrin-Rele…
Read guide →Abstract Background Gastrin-releasing peptide receptor (GRPR) attracts increasing attention as a target for radiotheranostic applications. We previously developed a metabolically stable GRPR-targeting peptide,…
Read guide →Introduction Prostate cancer is the leading cause of tumor-related death in men in the Western world. According to the estimation from the National Cancer Institute, about 240,890 new cases occurred in 2011, w…
Read guide →Section snippets Physiological GRPR Expression and Dosimetry Data in Healthy Human Tissues Peripheral physiological expression of GRPR include mostly the pancreas and the gastrointestinal tract.2, 3, 4 Partly …
Read guide →Abstract Background The gastrin-releasing peptide receptor (GRPR) has been extensively studied as a biomolecular target for peptide-based radiotheranostics. However, the lack of metabolic stability and the rap…
Read guide →Introduction of GRPR Gastrin-releasing peptide receptor (GRPR) is a seven-transmembrane-domain receptor of the GRPR superfamily. It is a mammalian homologue of the amphibian bombesin-like peptide receptor. GRP…
Read guide →Synonyms BB2, BB2R, bombesin receptor 2 + [6] Introduction Receptor for gastrin-releasing peptide (GRP) (PubMed: 1655761 ). Signals via association with G proteins that activate a phosphatidylinositol-calcium …
Read guide →Read the Full Video Transcript Andrei Iagaru: Thank you, Jeremie and, again, to the organizers for going beyond PSMA. And also could not have a better introduction to other hammers than this discussion. So I h…
Read guide →2 Expression and diagnosis of GRPR in some tumors Against this broader biological background, the oncologic overexpression of GRPR has attracted particular interest because it enables receptor-targeted molecul…
Read guide →Official Symbol GRPR provided by HGNC Official Full Name gastrin releasing peptide receptor provided by HGNC Primary source HGNC:HGNC:4609 See related Ensembl:ENSG00000126010 MIM:305670; AllianceGenome:HGNC:46…
Read guide →Introduction The gastrin-releasing peptide receptor (GRPR) is a receptor of the bombesin family and is overexpressed in 63–100% of primary prostate cancers 1 , 2 , 3 , 4 , 5 . Expression of GRPR in prostate ca…
Read guide →Review article Open access Under a Creative Commons license Author links open overlay panel , , , , The gastrin-releasing peptide receptor (GRPR) is known to be overexpressed in breast cancer, making it a prom…
Read guide →(UroToday.com) The 2025 PSMA and Beyond annual meeting featured new developments in genitourinary radioligand therapy session and a presentation by Dr. Andrei Iagaru discussing GRPR and other peptides for targ…
Read guide →Abstract Background Targeting the gastrin-releasing peptide receptor (GRPR) is a promising approach for radionuclide therapy in prostate and breast cancers. GRPR-targeting peptides often have limited metabolic…
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