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DSIP (Delta Sleep-Inducing Peptide) Named for promoting slow-wave (delta) sleep; the only one of the three tested directly for sleep in humans Preclinical + small, dated human studies — mixed to negative Best-controlled human tri…
Benzodiazepines (Valium, Xanax) and Z-drugs (Ambien, Lunesta) work by enhancing GABA-A receptor activity, which induces CNS depression. They suppress neural activity across the board, producing sedation rather than physiological …
DSIP Amplifies delta-wave oscillations in thalamus/cortex during NREM Stage 3 Increases slow-wave sleep duration by 18–34 min/night; no REM suppression 50–150mcg subcutaneous 30–60 min before bed Gradual; noticeable effects week …
Here's the honest answer: magnesium, L-theanine, glycine, and 5-HTP don't optimize sleep architecture. They might reduce sleep latency by 10–15 minutes. They might subjectively feel calming. But none of them increase slow-wave sl…
Pinealon Upregulates AANAT enzyme in pineal cells → increases endogenous melatonin synthesis Moderate (acts within 2–3 weeks) High (sustained endogenous production) Low (no receptor saturation) Best for long-term circadian restor…
Thymalin Thymic immune modulation. Normalizes T-cell function, reduces IL-6 and TNF-alpha Chronic inflammation reduction, endothelial protection 10–20 mg subcutaneous 2–3x weekly Targets downstream inflammation. Doesn't address a…
CJC-1295 vs Ipamorelin explained: different mechanisms, why they stack so well together, dosing protocols, side effects, and which to choose.
| Peptide | Primary Mechanism | Sleep Phase Affected | Research Maturity | Typical Dosing Range (Research Models) | Reconstitution Stability | Bottom Line ||—|—|—|—|—|—|| DSIP | Delta-opioid receptor agonism | Slow-wave (NREM Sta…