pramlintide fda approval year symlin 2005 FAQ

Adult dosage Injectable solution

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

Pramlintide is a prescription medication used to treat the symptoms of Type 1 and Type 2 Diabetes.

Symlin acts like a natural hormone in your body called amylin. It works to lower blood sugar levels by slowing stomach emptying, decreasing the amount of glucose (sugar) made by the liver, and regulating appetite.

Sterile injection: 5 ml vials, 600 mcg/ml. Multidose SymlinPen: 1000 mcg/ml (1.5 and 2.7 ml).

If you miss a dose, skip the missed dose and use the next dose at your next meal. Do not use double or extra doses.

Allergies to Ingredients. People who are allergic to any of the following should not use Symlin.

Common side effects of pramlintide include:

If you or someone else has used too much Symlin, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

Unopened Pen. Symlin should be stored in the refrigerator, between 36 F and 46 F (2 C and 8 C) before using it. Protect from light, and do not freeze. Do not use your pen if it has been frozen. Opened Pen. Once opened, Symlin can be stored at room temperature or in the refrigerator, between 36 F and 86 F (2 C and 30 C) for up to 30 days. Throw away the pen after 30 days, even if there is still medicine left. Do not use unopened or opened Symlin after the expiration date on the carton and prescription label.

Pramlintide should be administered under the skin (subcutaneously) prior to major meals. Patients with type 1 diabetes should start treatment with a dose of 15 mcg that is increased by 15 mcg increments to 30 or 60 mcg as tolerated. Treatment of type 2 diabetes should start with 60 mcg, the dose increasing to 120 mcg as needed. Insulin doses should be reduced when pramlintide is started.

Unopened vials and pen-injectors should be refrigerated between 2-8 C (36-46 F). Opened (in use) vials and pen-injectors should be refrigerated or kept at room temperature (no greater than 86 F, 30 C ) and used within 28 days.

There are no adequate studies of pramlintide in pregnant women. There are no adequate studies of pramlintide in nursing mothers, and it is not known if pramlintide is excreted in human breast milk.

For more information about Symlin, you can call the drugmaker at 800-236-9933.

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Symlin is right for you. In particular, make sure that you discuss any of the following. Current and Past Health Conditions. Tell your health care provider if you have any of the following.

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The most common side effects of Symlin are listed below. Tell your health care provider if you have any of these side effects that bother you.

Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. In particular, make sure that you discuss if you are using any of the following before using Symlin.

Pramlintide slows the transit of food through the intestine and, therefore, it should not be administered with other drugs that slow down the intestine (for example, atropine) or slow the absorption of food (for example, acarbose [Precose]). Pramlintide may interfere with (slow) the absorption of orally administered drugs. To avoid this interaction, orally administered drugs that require rapid absorption should be administered 1 hour before or 2 hours after injections of pramlintide. Insulin alters the chemical properties of pramlintide. Therefore, pramlintide and insulin should not be mixed in the same syringe.

Symlin (pramlintide) is commonly used as an add-on to insulin to help lower blood sugar in people with type 1 diabetes or type 2 diabetes. Symlin may also be used for other conditions as determined by your health care provider.