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GH Secretagogues (CJC-1295, Ipamorelin) Stimulate pituitary GH release → IGF-1 synthesis → mTOR activation 1.5–2.2 kg vs placebo Grip strength +10–15%, gait speed +0.08–0.12 m/s Subcutaneous injection, 100–200 mcg 2–3×/week Stron…
No published study has directly compared GHRPs, SARMs, and BPC-157 in the same sarcopenia cohort under identical protocols. Most trials isolate one compound class and compare it to placebo. The closest approximation comes from in…
CJC-1295 (DAC) GHRH analog. Stimulates pituitary GH release, elevates hepatic IGF-1 production, activates mTOR signaling 6–8 days 100mcg 2x/week subcutaneous Serum IGF-1 AUC, lean body mass (DEXA), muscle CSA (MRI) Gold standard …
CJC-1295 + Ipamorelin GHRH analog + ghrelin mimetic. Amplifies GH pulse amplitude and duration 200–300mcg each per injection 3–5 times weekly, pre-training or bedtime Moderate (Phase 2 trials, peer-reviewed observational data) St…
The table below compares the most researched peptide classes for sarcopenia based on mechanism, evidence quality, and practical considerations for research application. Ipamorelin Selective GHSR-1a agonist; stimulates pulsatile G…