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Modifying the activity of the gene that becomes mutated in Parkinson's disease may alter disease progression. Scientists have found specific genetic mutations that appear to have a role in Parkinson’s disease.…
Read guide →Apr 12, 2021 In Parkinson's disease, the death of substantia nigra dopamine-producing neurons unleashes a sequel of progressive motor and non-motor dysfunctions. There is no cure for this neurodegenerative dis…
Read guide →The new peptide shows promise as a drug precursor to treat Parkinson's disease, often known for its distinctive hand tremors. A molecule that shows promise in preventing Parkinson’s disease has been refined by…
Read guide →BACKGROUND Parkinson’s disease is a disabling and progressive neurological disorder characterized by degeneration of dopamine-producing neurons. Current therapies to replace dopamine are only symptomatic and a…
Read guide →In Alzheimer's, Parkinson's, and type 2 diabetes, harmful protein aggregates and deposits, known as amyloid plaques, develop. There is also much evidence that these three diseases are interconnected and mutual…
Read guide →Scientists from the University of Bath, working together with researchers at the Universities of Oxford and Bristol, have created a molecule that stops a key protein linked to Parkinson’s disease and certain d…
Read guide →Neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and Amyotrophic Lateral Sclerosis, also known as (ALS), affect millions of people worldwide and significantly imp…
Read guide →Abstract Peptides and their mimetics are increasingly recognised as drug-like molecules, particularly for intracellular protein-protein interactions too large for inhibition by small molecules, and inaccessibl…
Read guide →Objective/Rationale: Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) is currently one of the most potent factors protecting and rescuing neurons in pre-clinical models of Parkinson’s disease. We fou…
Read guide →Researchers at the Federal University of São Paulo (UNIFESP) in Brazil have discovered a new strategy that may protect neurons and other brain cells involved in Parkinson's disease in the future. The results o…
Read guide →Researchers at the University of Bath, in collaboration with the Universities of Oxford and Bristol, have developed a molecule that prevents the clumping and build-up of alpha-synuclein, a protein linked to Pa…
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