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Mike KS Chan Michelle BF Wong Wenyi Guo Michael Alexander Yuriy Nalapko Jonathan RT Lakey *Corresponding author: Jonathan R T Lakey, Department of Surgery, University of California Irvine, Irvine, California, …
Read guide →Modifying the activity of the gene that becomes mutated in Parkinson's disease may alter disease progression. Scientists have found specific genetic mutations that appear to have a role in Parkinson’s disease.…
Read guide →Apr 12, 2021 In Parkinson's disease, the death of substantia nigra dopamine-producing neurons unleashes a sequel of progressive motor and non-motor dysfunctions. There is no cure for this neurodegenerative dis…
Read guide →Search for topics, articles, videos, research, etc... Hit enter to search or ESC to close Study Rationale: Excess CDK5 protein kinase activity in the brain caused by the binding of CDK5 with another protein ca…
Read guide →Introduction Parkinson’s disease is a neurodegenerative condition typically observed in older individuals, characterized by a gradual onset and progressive nature. The initial manifestation often includes trem…
Read guide →BACKGROUND Parkinson’s disease is a disabling and progressive neurological disorder characterized by degeneration of dopamine-producing neurons. Current therapies to replace dopamine are only symptomatic and a…
Read guide →Scientists from the University of Bath, working together with researchers at the Universities of Oxford and Bristol, have created a molecule that stops a key protein linked to Parkinson’s disease and certain d…
Read guide →Objective/Rationale: Recently we have demonstrated that NF-kB activation is induced in vivo in the SNpc of Parkinson's disease patients and an MPTP-pre-clinical model, and that selective inhibition of NF-kB by…
Read guide →Neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and Amyotrophic Lateral Sclerosis, also known as (ALS), affect millions of people worldwide and significantly imp…
Read guide →Abstract Peptides and their mimetics are increasingly recognised as drug-like molecules, particularly for intracellular protein-protein interactions too large for inhibition by small molecules, and inaccessibl…
Read guide →Objective/Rationale: Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) is currently one of the most potent factors protecting and rescuing neurons in pre-clinical models of Parkinson’s disease. We fou…
Read guide →Researchers at the Federal University of São Paulo (UNIFESP) in Brazil have discovered a new strategy that may protect neurons and other brain cells involved in Parkinson's disease in the future. The results o…
Read guide →Researchers at the University of Bath, in collaboration with the Universities of Oxford and Bristol, have developed a molecule that prevents the clumping and build-up of alpha-synuclein, a protein linked to Pa…
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