Understand the source comparison
What the potency comparisons actually showed
In the classic anabolic studies, IGF analogs with reduced IGFBP binding — including Long R3 IGF-1 — produced greater nitrogen retention, greater gut and organ growth, and more pronounced anabolic responses than equimolar native IGF-1 in rodents, particularly i
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- In the classic anabolic studies, IGF analogs with reduced IGFBP binding — including Long R3 IGF-1 — produced greater nitrogen retention, greater gut and organ growth, and more pronounced anabolic responses than equimolar native IGF-1 in rodents, particularly in catabolic states such as dexamethasone treatment or dietary restriction.[5] These are rat and cell-culture findings. They establish that the analog is biologically more potent per molecule; they say nothing about safety, efficacy, or appropriate use in humans, for which there is no evidence base.