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VIP Help Shoemaker Protocol Research: Comparison Table
Shoemaker 2011 Case Series Pre-post observational 209 CIRS patients 73% showed biomarker normalisation; VCS improved 1.8 steps mean No placebo control, no independent replication, VIP not isolated from prior interventions Shoemaker 2013 NeuroQuant Study Pre-po
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- Shoemaker 2011 Case Series
- Pre-post observational
- 209 CIRS patients
- 73% showed biomarker normalisation; VCS improved 1.8 steps mean
- No placebo control, no independent replication, VIP not isolated from prior interventions
- Shoemaker 2013 NeuroQuant Study
- Pre-post imaging analysis
- 112 CIRS patients
- Caudate volume increased 5.2% over 6 months
- No control group, clinical significance of volumetric change unclear
- Murine Neuroinflammation Research (Journal of Immunology)
- Controlled animal model
- N/A (murine)
- VIP reduced microglial TNF-alpha by 60%
- Animal model. Human translation uncertain
- Independent RCT Data
- Does not exist
- 0
- No independent controlled trials published
- Absence of RCT-level evidence limits clinical confidence