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Storage Protocol for Lyophilised vs Reconstituted Tesofensine
Lyophilised tesofensine powder must be stored at −20°C (standard freezer temperature) before reconstitution. At this temperature, the peptide remains stable for 12–24 months when kept in its original sealed vial, protected from light and moisture. Freeze-thaw
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- Lyophilised tesofensine powder must be stored at −20°C (standard freezer temperature) before reconstitution. At this temperature, the peptide remains stable for 12–24 months when kept in its original sealed vial, protected from light and moisture. Freeze-thaw cycles should be minimised. Each cycle introduces condensation risk when the vial warms, and moisture exposure accelerates degradation even in powder form. If you need to transport lyophilised peptide, use an insulated cooler with ice packs rated to maintain sub-zero temperatures for the duration of transit.
- Once reconstituted with bacteriostatic water, transfer the vial immediately to refrigerated storage at 2–8°C. Do not leave reconstituted peptide at room temperature "to settle" or "to mix completely". These are unnecessary steps that introduce avoidable thermal stress. The reconstituted solution is stable for 28 days under continuous refrigeration, but that clock starts the moment water contacts the peptide, not when you first draw a dose. Researchers often assume the 28-day window applies only to "opened" vials, but peptide degradation in solution is a chemical process, not a contamination issue. It proceeds whether you've used the vial or not.
- Store the vial upright in the main refrigerator compartment, away from the door. Door storage exposes the vial to temperature fluctuations every time the refrigerator opens, and those micro-excursions compound over weeks. Avoid storing near the back wall where temperatures can drop below 2°C. While freezing won't immediately destroy the peptide, ice crystal formation during freezing can disrupt the solution and cause concentration inconsistencies. We've found that placing vials in a small container on the middle shelf provides the most stable microenvironment within standard household refrigerators.