Understand the source comparison
Tesofensine Triple Monoamine Reuptake: Mechanism Comparison
Tesofensine 6 nM 1.8 nM 11 nM Multi-modal metabolic and neuroscience research Cardiovascular signals (HR ↑, BP ↑) limit human dosing Bupropion 526 nM 1,580 nM >10,000 nM Dopamine/norepinephrine studies; weak DAT inhibition No meaningful serotonin activity Fluo
No winner is assigned.
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- Tesofensine
- 6 nM
- 1.8 nM
- 11 nM
- Multi-modal metabolic and neuroscience research
- Cardiovascular signals (HR ↑, BP ↑) limit human dosing
- Bupropion
- 526 nM
- 1,580 nM
- >10,000 nM
- Dopamine/norepinephrine studies; weak DAT inhibition
- No meaningful serotonin activity
- Fluoxetine
- 0.8 nM
- Selective serotonin research
- No dopamine or norepinephrine activity
- Phentermine
- Low affinity
- ~50–100 nM (indirect)
- Minimal
- Norepinephrine release studies
- No direct transporter binding; short half-life
- Cocaine
- 300 nM
- 400 nM
- 180 nM
- Comparative abuse liability studies
- Illegal; high abuse potential