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Senolytics versus telomere and cell-cycle approaches
FOXO4-DRI targets cells that have already become senescent — a clearance strategy. A different research thread aims further upstream, at the telomere biology and replicative clock that can drive cells toward senescence in the first place. The peptide Epithalon
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- FOXO4-DRI targets cells that have already become senescent — a clearance strategy. A different research thread aims further upstream, at the telomere biology and replicative clock that can drive cells toward senescence in the first place. The peptide Epithalon, for instance, has been studied for its reported effects on telomerase and aging biology; readers exploring that upstream angle can review our overview of Epithalon and telomerase aging research. The two approaches — clearing existing senescent cells versus influencing the pathways that create them — represent conceptually distinct bets, and neither is established as a human therapy.