Understand the source comparison
PE-22-28 vs Spadin vs Mini-Spadin: The Analog Family
PE-22-28 is best understood as one member of a designed family of TREK-1-blocking peptides, each representing a different engineering trade-off. Reviewing the family clarifies why PE-22-28 in particular attracted attention. Propeptide (PE) 44 aa; furin cleavag
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- PE-22-28 is best understood as one member of a designed family of TREK-1-blocking peptides, each representing a different engineering trade-off. Reviewing the family clarifies why PE-22-28 in particular attracted attention.
- Propeptide (PE)
- 44 aa; furin cleavage of sortilin
- Active parent fragment
- —
- Endogenous precursor
- Spadin (PE 12–28)
- 17 aa; natural fragment
- ~10 nM binding; IC50 ~40–60 nM
- ~7 hours
- First natural antidepressant peptide
- PE-22-28
- 7 aa; from spadin degradation products
- IC50 ~0.12 nM (patch-clamp)
- ~23 hours
- Higher potency + longer stability
- G/A-PE 22-28
- 7 aa; Gly/Ala-substituted variant
- Retained potent block
- Extended
- Enhanced neurogenic effect
- Retro-inverso analogs
- D-amino-acid, reversed backbone
- Retained antidepressant activity
- Increased
- Protease resistance
- Mini-spadin
- Shortened; sortilin-derived
- Biphasic (activation/inhibition)
- Stroke + post-stroke depression