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Prevention versus treatment
One of the most compelling findings from the 3xTg-AD studies was that P21 worked best when initiated early, during the synaptic compensation period before severe neurodegeneration had occurred. When treatment began at this stage, P21 prevented neurodegeneratio
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- One of the most compelling findings from the 3xTg-AD studies was that P21 worked best when initiated early, during the synaptic compensation period before severe neurodegeneration had occurred. When treatment began at this stage, P21 prevented neurodegeneration, prevented amyloid-beta and tau pathologies, rescued episodic memory, and markedly reduced mortality.
- This suggests that P21 may be most valuable as a preventive intervention rather than a treatment for advanced disease. For longevity-focused researchers, this has obvious implications. Preserving brain health before decline begins may be more effective than trying to restore it afterward.