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Peptides for Testosterone Replacement Protocol: Comparison
| Peptide | Mechanism of Action | Typical Dosing Protocol | Intratesticular T Preservation | Fertility Preservation | Practical Limitations | Professional Assessment ||—|—|—|—|—|—|| HCG (Human Chorionic Gonadotropin) | LH receptor agonist. Directly stimulates
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- | Peptide | Mechanism of Action | Typical Dosing Protocol | Intratesticular T Preservation | Fertility Preservation | Practical Limitations | Professional Assessment ||—|—|—|—|—|—|| HCG (Human Chorionic Gonadotropin) | LH receptor agonist. Directly stimulates Leydig cells to produce testosterone | 250–500 IU subcutaneous, 2–3× weekly | 60–75% of baseline maintained | Moderate. Preserves LH signal but not FSH; sperm counts maintained in 50–65% of users | Requires refrigeration; excessive doses increase estradiol conversion | Most practical first-line option for testicular function preservation during TRT. Evidence base is strongest and adherence is highest || Gonadorelin (Synthetic GnRH) | GnRH receptor agonist. Stimulates pituitary LH and FSH release in physiological pulses | 25–50 mcg pulsed every 90–120 min via pump, or 100–150 mcg 3–4× daily SC injection | 70–80% of baseline maintained | High. Stimulates both LH and FSH, preserving spermatogenesis in 70–80% of users | Requires pump