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Peptides for Testosterone Boost: Mechanism Comparison
| Peptide | Target Receptor | Mechanism | Half-Life | Typical Dosing | Primary Use Case | Professional Assessment ||—|—|—|—|—|—|| Kisspeptin-10 | GPR54 (hypothalamus) | Stimulates pulsatile GnRH release | 28 minutes | 0.24 nmol/kg SC daily | Functional hypogon
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- | Peptide | Target Receptor | Mechanism | Half-Life | Typical Dosing | Primary Use Case | Professional Assessment ||—|—|—|—|—|—|| Kisspeptin-10 | GPR54 (hypothalamus) | Stimulates pulsatile GnRH release | 28 minutes | 0.24 nmol/kg SC daily | Functional hypogonadism, blunted GnRH tone | Most physiologic. Preserves entire HPG axis but requires frequent dosing || Gonadorelin | GnRH receptors (pituitary) | Direct GnRH agonist, stimulates LH/FSH | 2–10 minutes | 25–100 mcg pulsatile every 90–120 min | Hypogonadotropic hypogonadism, impaired hypothalamic signaling | Effective but logistically complex. Requires infusion pump for pulsatile delivery || hCG | LH/hCG receptors (Leydig cells) | LH analogue, directly stimulates testosterone synthesis | 24–36 hours | 250–500 IU SC twice weekly | TRT preservation, primary hypogonadism, anabolic steroid PCT | Most practical for sustained testosterone support. Bypasses upstream failures || Clomiphene (SERM) | Estrogen receptors (hypothalamus/pituitary)