Understand the source comparison
Peptides for Cancer Research Peptides: Synthesis Method Comparison
Standard SPPS (Fmoc chemistry) 85–95% (crude), 95–98% (HPLC purified) 60–80% $200–$400 Linear peptides, standard sequences, general screening Industry standard. Reliable for most research applications; purification quality determines reproducibility Microwave-
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- Standard SPPS (Fmoc chemistry)
- 85–95% (crude), 95–98% (HPLC purified)
- 60–80%
- $200–$400
- Linear peptides, standard sequences, general screening
- Industry standard. Reliable for most research applications; purification quality determines reproducibility
- Microwave-assisted SPPS
- 90–98% (crude), 98–99.5% (HPLC purified)
- 70–90%
- $300–$600
- Difficult sequences (high Pro, Arg content), cyclised peptides
- Faster coupling kinetics reduce deletion sequences. Worth the premium for complex targets
- Recombinant expression (E. coli)
- 90–95% (post-purification)
- Variable (0.5–5 mg/L culture)
- $50–$150 (at scale)
- Long peptides (>40 residues), large batch requirements
- Cost-effective at scale but limited to non-modified sequences; not suitable for D-amino acids or cyclisation
- Custom solid-phase with non-natural amino acids
- 95–99% (HPLC purified)
- 50–70%
- $500–$1,200
- Stapled peptides, D-amino acid substitutions, protease-resistant analogs
- Essential for in vivo stability studies. Natural sequences degrade too quickly for animal models