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Peptides for Adrenal Support Protocol Evidence Guide: Clinical Comparison
Thymalin (thymus polypeptide) CRH downregulation via T-reg cytokine signaling Hypothalamus (paraventricular nucleus) 10mg SC every 72 hours RCT (n=64, 2018) 18–22% at 30 days Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) GABA-A receptor potentiation Amygdala, prefronta
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- Thymalin (thymus polypeptide)
- CRH downregulation via T-reg cytokine signaling
- Hypothalamus (paraventricular nucleus)
- 10mg SC every 72 hours
- RCT (n=64, 2018)
- 18–22% at 30 days
- Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro)
- GABA-A receptor potentiation
- Amygdala, prefrontal cortex
- 600mcg intranasal BID
- Double-blind RCT (n=48, 2020)
- 40% evening cortisol reduction at 21 days
- Epithalon (Ala-Glu-Asp-Gly)
- Pineal melatonin normalization, circadian HPA entrainment
- Pineal gland
- 10mg SC daily for 10 days, then 20-day pause
- Observational (n=32, 2019)
- 12–15% improvement in cortisol slope
- P21 (NAPVSIPQ dipeptide derivative)
- BDNF upregulation, neuroplasticity support
- Hippocampus
- 10mg SC 3x/week
- Preclinical only
- No cortisol data