Understand the source comparison
Best Peptides for Adrenal Fatigue: Research Compound Comparison
Thymalin Thymic regeneration; restores T-regulatory cell production and reduces inflammatory cytokines 5-10mg SC every 48 hours for 10 doses Lyophilized: -20°C; reconstituted: 2-8°C, use within 28 days Immune-endocrine axis Best first-line peptide for HPA dysf
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Thymalin
- Thymic regeneration; restores T-regulatory cell production and reduces inflammatory cytokines
- 5-10mg SC every 48 hours for 10 doses
- Lyophilized: -20°C; reconstituted: 2-8°C, use within 28 days
- Immune-endocrine axis
- Best first-line peptide for HPA dysfunction—addresses the immune dysregulation that perpetuates stress response abnormalities
- MK-677
- Growth hormone secretagogue; stimulates pulsatile GH release and IGF-1 production
- 25mg oral daily for 12-16 weeks
- Room temperature (lyophilized); refrigerate liquid forms
- Anabolic signaling, mitochondrial biogenesis
- Most practical for long-term use—oral administration and stable GH elevation make it ideal for sustained recovery
- Cerebrolysin
- Neurotrophic peptide mixture; promotes hippocampal neurogenesis and synaptic repair
- 5-10ml IM or IV 2-3x weekly for 8-12 weeks
- Refrigerate at 2-8°C; do not freeze
- Central nervous system, HPA feedback regulation
- Strongest evidence for reversing stress-induced hippocampal atrophy—critical for restoring cognitive function and emotional resilience
- Dihexa
- Hepatocyte growth factor modulator; enhances synaptogenesis and cognitive processing
- 1-5mg oral or SC daily (research dose range)
- Room temperature (lyophilized); refrigerate once reconstituted
- Cognitive function, neural plasticity
- Emerging compound with potent synaptic effects—less studied than Cerebrolysin but promising for cognitive recovery