Understand the source comparison
Peptide Comparison: Energy Mechanisms
Ipamorelin Stimulates pituitary GH release via ghrelin receptor activation without cortisol spike 200–300mcg 2–3× daily ~2 hours Fasted state (3+ hours post-meal) Best for gradual energy improvement over weeks. Not immediate effect CJC-1295 (no DAC) Amplifies
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Ipamorelin
- Stimulates pituitary GH release via ghrelin receptor activation without cortisol spike
- 200–300mcg 2–3× daily
- ~2 hours
- Fasted state (3+ hours post-meal)
- Best for gradual energy improvement over weeks. Not immediate effect
- CJC-1295 (no DAC)
- Amplifies GH pulses by extending GHRH half-life, synergistic with ipamorelin
- 100–200mcg 1–2× daily
- 6–8 hours
- Morning fasted or pre-bed
- Reduces injection frequency vs ipamorelin alone. Requires consistent timing
- MOTS-c
- Enhances mitochondrial glucose uptake and AMPK activation. Cellular energy at ATP level
- 5–10mg once daily
- 4–6 hours
- Morning (food timing irrelevant)
- Most direct impact on exercise capacity and metabolic rate. Not GH-dependent
- Hexarelin
- Dual GHS-R and CD36 receptor agonist. Stronger GH pulse but also elevates cortisol/prolactin
- 100mcg 1–2× daily
- ~70 minutes
- Fasted state, short cycles only (4–6 weeks)
- Most potent GH release but cannot be used long-term. Receptor desensitization occurs
- MK-677 (oral)
- Non-peptide ghrelin mimetic. Continuous GH elevation with no injections
- 10–25mg once daily (oral)
- 24 hours
- Bedtime preferred (appetite increase)
- Convenient but causes significant water retention and hunger. Compliance easier than injections