Understand the source comparison
How to Use Peptides for Wound Healing: Mechanism Comparison
BPC-157 Angiogenesis via VEGF upregulation + fibroblast migration Proliferative (days 3–10) 200–500mcg per application Subcutaneous injection near wound site 2–8°C for 28 days (bacteriostatic water) TB-500 (Thymosin Beta-4) Actin polymerization + keratinocyte
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- BPC-157
- Angiogenesis via VEGF upregulation + fibroblast migration
- Proliferative (days 3–10)
- 200–500mcg per application
- Subcutaneous injection near wound site
- 2–8°C for 28 days (bacteriostatic water)
- TB-500 (Thymosin Beta-4)
- Actin polymerization + keratinocyte migration
- Inflammatory to early proliferative (days 1–7)
- 2–5mg per application
- Subcutaneous or intramuscular
- GHK-Cu
- Collagen synthesis + MMP regulation + copper delivery
- Proliferative to remodeling (days 5–21)
- 1–3% topical concentration
- Direct wound bed application
- 2–8°C for 14 days (aqueous formulation)
- Bottom Line
- BPC-157 for vascular wounds, TB-500 for acute trauma, GHK-Cu for chronic ulcers
- Match peptide mechanism to wound pathology. Not all peptides work for all wound types
- Subcutaneous delivery outperforms topical for systemic wounds; topical works for surface ulcers
- Temperature control determines whether you're administering active peptide or denatured protein