Understand the source comparison
How to Use Peptides for Sleep: Type Comparison
DSIP (Delta Sleep-Inducing Peptide) Modulates delta-wave activity through GABAergic signaling and stress hormone suppression 100–500mcg subcutaneous 30–45 minutes before bed Increases slow-wave sleep duration by 15–25%; reduces sleep latency modestly Best for
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- DSIP (Delta Sleep-Inducing Peptide)
- Modulates delta-wave activity through GABAergic signaling and stress hormone suppression
- 100–500mcg subcutaneous
- 30–45 minutes before bed
- Increases slow-wave sleep duration by 15–25%; reduces sleep latency modestly
- Best for stress-related insomnia where cortisol disrupts sleep onset
- GHRP-2 / GHRP-6
- Growth hormone secretagogue receptor agonist; triggers endogenous GH pulse
- 100–300mcg subcutaneous
- 60 minutes before bed on empty stomach
- Deepens slow-wave sleep; improves sleep continuity; may increase REM latency slightly
- Effective for fragmented sleep and poor sleep maintenance
- Ipamorelin
- Selective GHSR agonist with minimal cortisol or prolactin elevation
- 200–300mcg subcutaneous
- 30–60 minutes before bed
- Enhances slow-wave sleep without hormonal side effects; well-tolerated long-term
- Cleanest profile for chronic use. Low side effect burden
- Sermorelin (GHRH analogue)
- Stimulates pituitary GHRH receptors to release growth hormone
- 200–500mcg subcutaneous
- 30 minutes before bed
- Restores age-related decline in GH-mediated sleep depth; gradual effect over 2–3 weeks
- Best for individuals over 40 with declining endogenous GH secretion