Understand the source comparison
How to Read AOD-9604 COA: Analytical Method Comparison
HPLC Purity Proportion of sample that is target peptide vs impurities ≥98% for research-grade Verifies synthesis quality and homogeneity. Low purity means you're dosing with unknown compounds Purity <95%, multiple large peaks on chromatogram, no chromatogram p
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- HPLC Purity
- Proportion of sample that is target peptide vs impurities
- ≥98% for research-grade
- Verifies synthesis quality and homogeneity. Low purity means you're dosing with unknown compounds
- Purity <95%, multiple large peaks on chromatogram, no chromatogram provided
- A clean single-peak chromatogram at 98%+ purity is the baseline for reliable research. Anything less introduces variables you can't control
- Mass Spectrometry (MS)
- Molecular weight to confirm peptide identity
- 1815.08 Da ± 0.5 Da
- Confirms the peptide is actually AOD-9604 and not a synthesis error or substitution
- Reported mass outside 1814.5–1815.6 Da range, vague ranges instead of precise measurement, MS data missing entirely
- MS is the definitive identity test. Without it, you're trusting the label with no chemical verification
- Peptide Content
- Actual peptide mass as percentage of total powder mass
- 85–95%
- Determines how much active compound you're actually reconstituting per mg of powder
- Content <80%, no peptide content reported, vial weight doesn't match stated content
- Low peptide content means you're paying for excipients and calculating doses incorrectly. This compounds across every experiment
- Endotoxin Level (LAL)
- Bacterial endotoxin contamination
- <1.0 EU/mg (ideally <0.1 EU/mg for in vivo work)
- Prevents immune activation that confounds biological assays and in vivo studies
- Endotoxin >1.0 EU/mg, no endotoxin testing reported, LAL method not specified
- Endotoxins are invisible contaminants that invalidate immune-related research. If the COA doesn't report this, don't use the peptide in vivo
- Sterility (USP <71>)
- Presence of viable bacteria or fungi
- No growth detected after incubation
- Ensures peptide won't introduce microbial contamination during reconstitution or storage
- Growth detected, sterility test not performed, testing method not specified
- Sterility failure means every subsequent dose introduces contamination risk. Non-negotiable for multi-dose vials