Understand the source comparison
Glutathione Dosage Comparison — Heavy Metal Detox Forms
Reduced L-Glutathione (oral) 1000–3000mg daily 10–20% (extensive gastric degradation) Budget-conscious protocols where high doses are acceptable Split into 2–3 doses, away from meals Requires 3–5× higher dose than liposomal to achieve comparable intracellular
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Reduced L-Glutathione (oral)
- 1000–3000mg daily
- 10–20% (extensive gastric degradation)
- Budget-conscious protocols where high doses are acceptable
- Split into 2–3 doses, away from meals
- Requires 3–5× higher dose than liposomal to achieve comparable intracellular levels. First-pass loss is the limiting factor
- Liposomal Glutathione
- 500–1000mg daily
- 60–80% (phospholipid protection through GI tract)
- First-line choice for detox protocols; best cost-efficacy ratio
- Once daily, morning preferred
- Gold standard for oral GSH. Absorption efficiency justifies higher cost per milligram
- S-Acetyl-Glutathione (SAG)
- 300–600mg daily
- 50–70% (acetyl group enhances cellular uptake)
- Sensitive GI systems; those who respond poorly to liposomal
- Once or twice daily with food
- Underutilized form. Particularly effective when combined with NAC for dual-pathway support
- N-Acetylcysteine (NAC)
- 600–1200mg twice daily
- N/A (precursor, not direct GSH)
- Supports endogenous synthesis; ideal for long-term maintenance
- Twice daily, 12 hours apart
- Doesn't deliver GSH directly but removes the absorption bottleneck. Effective when oral GSH fails
- IV Glutathione
- 1000–2000mg per session, 1–3× weekly
- ~100% (bypasses GI degradation entirely)
- Acute detox phases, high body burden, or GI malabsorption
- Clinical setting only, not for home use
- Most direct route but requires medical oversight. Reserved for cases where oral forms are insufficient