Understand the source comparison
Best Glutathione Dosage for Liver Health: Protocol Comparison
Reduced L-Glutathione (Standard) 500–1000mg 2–3 divided doses ALT/AST reduction, hepatic steatosis improvement (NAFLD trials) Requires higher doses due to first-pass metabolism. Take on empty stomach for better absorption Liposomal Glutathione 250–500mg 1–2 di
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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Reduced L-Glutathione (Standard)
- 500–1000mg
- 2–3 divided doses
- ALT/AST reduction, hepatic steatosis improvement (NAFLD trials)
- Requires higher doses due to first-pass metabolism. Take on empty stomach for better absorption
- Liposomal Glutathione
- 250–500mg
- 1–2 divided doses
- Plasma glutathione elevation, intracellular GSH/GSSG ratio normalization
- Superior bioavailability allows lower effective doses. Ideal for maintenance protocols
- S-Acetyl-Glutathione (SAG)
- 200–400mg
- Plasma and erythrocyte glutathione concentrations
- Acetyl protection improves absorption. Limited liver-specific clinical trial data
- N-Acetyl-Cysteine (NAC)
- 600–1800mg
- Hepatic glutathione synthesis, ALT normalization in acetaminophen toxicity
- Precursor approach. Works best when glutathione synthesis pathways are intact but substrate-limited
- Sublingual Glutathione
- 100–200mg
- 1–2 times daily
- Plasma glutathione (limited hepatic endpoint data)
- Bypasses GI breakdown but lacks robust liver-specific clinical validation