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Fat storage versus fat burning
NNMT does not just affect NAD+ levels. It also influences gene expression patterns that control whether cells store or burn fat. When NNMT activity is high, fat cells become more efficient at lipogenesis, the process of creating and storing fat. The cells also
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- NNMT does not just affect NAD+ levels. It also influences gene expression patterns that control whether cells store or burn fat. When NNMT activity is high, fat cells become more efficient at lipogenesis, the process of creating and storing fat. The cells also become more resistant to lipolysis, the breakdown of stored fat for energy.
- Research has shown that blocking NNMT can reduce lipogenesis by 50 to 70 percent in adipocytes compared to untreated controls. This is a substantial shift in cellular behavior that directly affects body composition.
- Additionally, NNMT inhibition appears to increase expression of GLUT4 transporters, which move glucose from the bloodstream into cells. Improved glucose uptake means better blood sugar regulation and less excess glucose available to be converted into fat.