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DSIP vs Orexin Receptor Antagonists
Orexin receptor antagonists, such as suvorexant, promote sleep by inhibiting wake-promoting neuropeptides. DSIP, in contrast, appears to facilitate sleep initiation and depth via slow-wave promotion rather than wakefulness suppression. Direct head-to-head effi
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- Orexin receptor antagonists, such as suvorexant, promote sleep by inhibiting wake-promoting neuropeptides. DSIP, in contrast, appears to facilitate sleep initiation and depth via slow-wave promotion rather than wakefulness suppression. Direct head-to-head efficacy studies are not available.