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DSIP vs Antidepressants (Used Off-Label)

Certain antidepressants, including trazodone and mirtazapine, are prescribed off-label for insomnia due to sedative properties. These agents may alter sleep architecture, often increasing REM latency. DSIP may provide sleep enhancement without disrupting REM,

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  • Certain antidepressants, including trazodone and mirtazapine, are prescribed off-label for insomnia due to sedative properties. These agents may alter sleep architecture, often increasing REM latency. DSIP may provide sleep enhancement without disrupting REM, but clinical data remain insufficient for definitive comparison.