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DSIP Results Timeline: Phase Comparison
Understanding the DSIP results timeline requires distinguishing between acute pharmacological effects and long-term physiological re-regulation. The table below maps the three primary outcome phases, their measurable biomarkers, and the typical onset windows o
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- Understanding the DSIP results timeline requires distinguishing between acute pharmacological effects and long-term physiological re-regulation. The table below maps the three primary outcome phases, their measurable biomarkers, and the typical onset windows observed across peer-reviewed protocols.
- Acute Sleep Onset
- Days 1–10
- Sleep latency, PSQI score
- 8–14 min latency reduction, 2+ point PSQI improvement
- Subjective quality improves; sleep architecture unchanged
- REM and Delta Modulation
- Weeks 2–4
- SWS %, REM latency, sleep efficiency
- SWS increases 16% → 22%, efficiency 72% → 84%
- Deep sleep restoration; cortisol rhythm begins normalizing
- HPA Axis Regulation
- Weeks 4–8
- Morning/evening cortisol, HRV
- Morning cortisol +20%, evening cortisol −25%, HRV increases
- Circadian re-entrainment; autonomic balance restored
- The table makes clear why single-week pilot studies consistently underestimate DSIP's therapeutic potential: the endpoints researchers care most about. HPA axis regulation, circadian stability, autonomic balance. Don't emerge until weeks four through six. Acute sleep latency improvements are real but aren't the mechanism driving long-term benefit.