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Comparison of Peptides Used in Stress & Anxiety Research
The table below compares the most frequently investigated peptides in stress and anxiety research, detailing primary mechanisms, receptor targets, and research applications. Selank Amidate Enkephalin stabilization, GABAergic modulation Enkephalin-degrading enz
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- The table below compares the most frequently investigated peptides in stress and anxiety research, detailing primary mechanisms, receptor targets, and research applications.
- Selank Amidate
- Enkephalin stabilization, GABAergic modulation
- Enkephalin-degrading enzyme inhibition, indirect GABA support
- Generalized anxiety models, stress-induced immune suppression
- Most studied anxiolytic peptide with human clinical data; non-sedating profile makes it ideal for cognitive performance studies
- Semax Amidate
- BDNF upregulation, dopamine stabilization
- TrkB receptor (BDNF), dopamine transporter modulation
- Chronic stress resilience, cognitive fatigue, anhedonia models
- Strong neuroplasticity signal; particularly relevant for stress conditions with cognitive impairment component
- P21
- Synaptic plasticity via CREB activation
- CREB pathway, hippocampal neurogenesis support
- Fear extinction, PTSD models, chronic anxiety with memory impairment
- Mechanistically distinct from anxiolytics; facilitates adaptive learning rather than symptom suppression
- Cerebrolysin
- Neurotrophic factor cocktail (BDNF, NGF, CNTF analogs)
- Multiple neurotrophic receptors
- Stress-induced neurodegeneration, cognitive decline under chronic stress
- Broad-spectrum neurotrophic support; less selective than single-target peptides but clinically validated in neurology contexts
- Thymalin
- Thymic peptide, immune-HPA axis modulation
- Thymic hormone receptors, cytokine regulation
- Stress-induced immunosuppression, psychoneuroimmunology research
- Bridges immune and neuroendocrine systems; useful for models where stress impacts immune function