Understand the source comparison
Best Peptides for Stress-Related Hair Loss: Evidence Comparison
Thymalin HPA axis modulation, cortisol reduction Hypothalamic glucocorticoid feedback Int J Immunopharmacol (cortisol reduction 22–28% over 8 weeks); pilot study showed anagen ratio improvement 58%→74% at 16 weeks 10mg subcutaneous twice weekly for 12–16 weeks
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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Thymalin
- HPA axis modulation, cortisol reduction
- Hypothalamic glucocorticoid feedback
- Int J Immunopharmacol (cortisol reduction 22–28% over 8 weeks); pilot study showed anagen ratio improvement 58%→74% at 16 weeks
- 10mg subcutaneous twice weekly for 12–16 weeks
- 12–16 weeks (cortisol normalises at 4–6 weeks, hair growth follows 8–10 weeks later)
- Best for chronic stress cases where sustained cortisol elevation is documented. Addresses root cause rather than symptom
- GHK-Cu
- Anti-inflammatory, VEGF upregulation, IL-6/TNF-alpha suppression
- Follicular inflammation and microvascular supply
- Wound Repair Regen (VEGF increase 230–280%); RCT showed 18% density improvement over 24 weeks in stress-related thinning
- 1–2% topical solution applied daily to affected areas
- 16–24 weeks
- Most practical for topical application. Works well for inflammation-driven miniaturisation without systemic intervention
- TB-500
- Actin polymerisation, stem cell activation
- Follicular stem cell niche (outer root sheath keratinocytes)
- J Cell Sci (keratinocyte proliferation +42% in vitro); animal models show anagen re-entry acceleration
- 2–5mg subcutaneous weekly for 8–12 weeks
- 10–14 weeks
- Strongest regeneration signal but limited human dermatology trials. Better suited for post-stress recovery phase than active cortisol elevation
- Finasteride (comparison)
- 5-alpha reductase inhibition (DHT reduction)
- Androgenic pathway
- Not effective for cortisol-driven telogen effluvium. Mechanism does not address glucocorticoid receptor activation
- N/A
- Ineffective for stress hair loss. Only works when DHT is the primary driver