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Best Peptides for Marathon Runners: Evidence Comparison
BPC-157 VEGF upregulation, collagen synthesis Tendon repair, chronic injury recovery 250–500 mcg SubQ 1–2x daily Animal models + anecdotal (no human RCTs) Strong mechanistic basis; most reliable for localized soft tissue healing TB-500 Actin polymerization, ce
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- BPC-157
- VEGF upregulation, collagen synthesis
- Tendon repair, chronic injury recovery
- 250–500 mcg SubQ 1–2x daily
- Animal models + anecdotal (no human RCTs)
- Strong mechanistic basis; most reliable for localized soft tissue healing
- TB-500
- Actin polymerization, cell migration
- Systemic inflammation, muscle recovery
- 2–2.5 mg SubQ 2x weekly (loading), then 2 mg weekly
- Animal + limited human pilot data
- Effective for reducing downtime between hard training blocks; broader anti-inflammatory effect than BPC-157
- MOTS-c
- AMPK activation, mitochondrial biogenesis
- VO2 max, lactate threshold, endurance capacity
- 5–10 mg SubQ 2–3x weekly
- Preclinical + early human metabolic studies
- Amplifies training adaptation; best used during base-building or VO2 max phases
- Semax
- BDNF upregulation, cognitive resilience
- Mental endurance, focus, perceived exertion
- 300–600 mcg intranasal daily
- Human cognitive performance trials
- Noticeable subjective effect; underutilized for mental pacing in distance running
- Thymosin Alpha-1
- IL-2/IFN-gamma production, T-cell function
- Immune resilience, illness prevention
- 750 mcg–1.5 mg SubQ 2x weekly
- FDA-approved (chronic viral infections); limited sports data
- Most valuable for high-mileage athletes prone to recurrent infections during training