Understand the source comparison
Best Peptides for Female Infertility: Mechanism Comparison
Follistatin Binds activin to enhance FSH receptor sensitivity in granulosa cells Diminished ovarian reserve, poor responder protocols 1–3 mg/kg subcutaneously during early follicular phase Subcutaneous injection Promising for DOR but limited Phase II data. Not
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Follistatin
- Binds activin to enhance FSH receptor sensitivity in granulosa cells
- Diminished ovarian reserve, poor responder protocols
- 1–3 mg/kg subcutaneously during early follicular phase
- Subcutaneous injection
- Promising for DOR but limited Phase II data. Not yet standard of care
- Kisspeptin-10/54
- Activates GPR54 receptors on GnRH neurons to restore pulsatile GnRH release
- Functional hypothalamic amenorrhea, ovulation induction
- 6.4–12.8 nmol/kg subcutaneously 34–36 hours pre-ovulation
- Highly effective for FHA but requires precise timing and rapid use after reconstitution
- GnRH Agonists
- Initial flare then pituitary desensitization to suppress endogenous LH/FSH
- Long IVF protocols, endometriosis suppression
- 0.5–1 mg daily or depot formulation
- Subcutaneous or intramuscular
- Gold standard for controlled stimulation but higher OHSS risk than antagonists
- GnRH Antagonists
- Immediate competitive blockade of GnRH receptors
- Short IVF protocols, PCOS patients
- 0.25 mg daily starting mid-follicular phase
- Preferred for most modern protocols. Lower side effect profile, equal efficacy