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Best Peptides for Fat Burning: Mechanism Comparison
GLP-1 Agonists (semaglutide, tirzepatide) Appetite suppression via hypothalamic GLP-1 receptor activation + delayed gastric emptying Reduced caloric intake (20–30% deficit) STEP-1: 14.9% weight loss at 68 weeks; SURMOUNT-1: 20.9% at 72 weeks Appetite regulatio
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- GLP-1 Agonists (semaglutide, tirzepatide)
- Appetite suppression via hypothalamic GLP-1 receptor activation + delayed gastric emptying
- Reduced caloric intake (20–30% deficit)
- STEP-1: 14.9% weight loss at 68 weeks; SURMOUNT-1: 20.9% at 72 weeks
- Appetite regulation studies, metabolic syndrome intervention, satiety hormone dynamics
- No direct lipolysis. Requires caloric deficit
- Growth Hormone Secretagogues (CJC-1295, ipamorelin, hexarelin)
- Pituitary GH release → HSL activation in adipocytes → triglyceride hydrolysis
- Direct lipolysis through cAMP-mediated fat cell breakdown
- JCEM: 200–400% GH elevation, 40–60% FFA increase within 2 hours
- Lipolysis mechanism research, body recomposition studies, GH secretion kinetics
- Requires energy expenditure for FFA oxidation. Liberated FFAs re-esterify without utilization
- Metabolic Modulators (tesofensine, survodutide)
- Norepinephrine/dopamine/serotonin reuptake inhibition → beta-3 adrenergic receptor activation in BAT → UCP1 thermogenesis
- Increased resting metabolic rate (6–10% elevation) independent of caloric intake
- Phase III: 10.6% weight loss at 24 weeks with tesofensine 0.5mg daily
- Thermogenesis research, brown adipose tissue activation studies, metabolic rate modulation
- CNS stimulation profile. Requires monitoring for cardiovascular effects